115956-12-2

115956-12-2 structure

Name: Dolasetron
Chemical Name: (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
CAS Number: 115956-12-2
Molecular Formula: C₁₉H₂₀N₂O₃
Molecular Weight: 324.37400
Catalog: API Digestive system medication Antiemetic emetic
Create Date: 2018-06-18 19:55:21
Modify Date: 2025-08-22 09:33:34
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Name	(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
Synonyms	Dolasetronum [inn-latin] Dolasetron (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid,octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester 1H-Indole-3-carboxylic acid,octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester,(2alpha,6alpha,8alpha,9abeta) Dolasetronum Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester Unii-82wi2L7Q6e

Description	Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Others
References	[1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8. [2]. Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014 Feb;22(2):469-77.

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing .
WGK Germany	3