123694-03-1

123694-03-1 structure

Name: Osmundacetone
Chemical Name: 4-(3,4-dihydroxyphenyl)but-3-en-2-one
CAS Number: 123694-03-1
Molecular Formula: C₁₀H₁₀O₃
Molecular Weight: 178.18500
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-12-02 15:36:53
Modify Date: 2025-10-24 19:40:33
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].

Name	4-(3,4-dihydroxyphenyl)but-3-en-2-one
Synonyms	3,4-dihydroxybenzalacetone 4-(3,4-dihydroxyphenyl)-(E)-3-buten-2-one 4-(3,4-Dihydroxyphenyl)-3-buten-2-one 4-(3,4-dihydroxy-phenyl)-but-3-en-2-one (3E)-4-(3,4-dihydroxyphenyl)-but-3-en-2-one 3-Buten-2-one,4-(3,4-dihydroxyphenyl)-,(3E) MFCD00916691 4-(3,4-Dihydroxy-phenyl)-but-3-en-2-on 3-Buten-2-one,4-(3,4-dihydroxyphenyl)-,(E) (E)-3,4-Dihydroxybenzylideneacetone Osmundacetone

Description	(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Tuy An Trinh, et al. Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. Biomolecules.2021 Feb 22;11(2):328.

139-85-5

~14%

123694-03-1

Literature: US2003/144316 A1, ;

67-64-1

139-85-5

~54%

123694-03-1

Literature: Synthetic Communications, , vol. 33, # 6 p. 1019 - 1045

6515-06-6

123694-03-1

Literature: Bioscience, Biotechnology and Biochemistry, , vol. 74, # 4 p. 741 - 745