63735-71-7
63735-71-7 structure
- Name: AEG 3482
- Chemical Name: 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
- CAS Number: 63735-71-7
- Molecular Formula: C10H8N4O2S2
- Molecular Weight: 280.326
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-18 00:27:52
- Modify Date: 2024-01-04 18:42:59
-
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1].
| Name | 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide |
|---|---|
| Synonyms |
hms1538b12
6-Phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide Imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 6-phenyl- unii-7ezf1a283n |
| Description | AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1]. |
|---|---|
| Related Catalog | |
| Target |
JNK[1] |
| In Vitro | AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM[1]. AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1]. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells[1]. Apoptosis Analysis[1] Cell Line: PC12 cells Concentration: 1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time: 40 hours Result: Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM. Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 10, 20, 40 μM Incubation Time: 30 hours Result: Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H8N4O2S2 |
| Molecular Weight | 280.326 |
| Exact Mass | 280.008881 |
| PSA | 126.97000 |
| LogP | 1.32 |
| Index of Refraction | 1.835 |
|
~48%
63735-71-7 |
| Literature: Barnish; Cross; Dickinson; Gadsby; Parry; Randall; Sinclair Journal of medicinal chemistry, 1980 , vol. 23, # 2 p. 117 - 121 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |