514200-66-9

514200-66-9 structure

Name: COG 133
Chemical Name: cog 133
CAS Number: 514200-66-9
Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉
Molecular Weight: 2169.71000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-01-21 12:28:01
Modify Date: 2024-01-13 11:50:59
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].

Name	cog 133

Description	COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	IC50: 445 nM (nAChR)[2]
References	[1]. Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35. [2]. Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316(2):835-42.