Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sirtinol
Price: ￥1746.0/25mg ￥536.0/5mg ￥5646.0/100mg ￥3306.0/50mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Sirtinol
Price: $350.0/100mg $630.0/250mg $1250.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SIRTINOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

410536-97-9

410536-97-9 structure

410536-97-9 structure

Name: Sirtinol
Chemical Name: Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
CAS Number: 410536-97-9
Molecular Formula: C₂₆H₂₂N₂O₂
Molecular Weight: 394.465
Catalog: Biochemical Inhibitor Epigenetics Sirtuin inhibitor
Create Date: 2018-12-04 17:18:09
Modify Date: 2024-01-02 20:46:30
Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.

Name	Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Synonyms	2-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-(1-phenylethyl)benzamide 2-{[(E)-(2-Hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide sir two inhibitor naphthol sirtinol 2-{(E)-[(2-Hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide Benzamide, 2-[[(1E)-(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-

Description	Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer
Target	ySir2:48 μM (IC50) hSIRT2:57.7 μM (IC50) hSIRT1:131 μM (IC50)
In Vitro	Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level[1]. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1[2].
In Vivo	Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury[3].
Cell Assay	Sirtinol is dissolved in 100% DMSO at concentration of 10 mM and stored at −20°C until use. The cell proliferation of H1299 cells is determined by trypan blue dye exclusion assay. Human nonsmall cell lung cancer (NSCLC) cells are seeded in 12-well plates and treated with indicated concentrations of sirtinol (0, 10, 20, and 50 μM) for 24 h and 48 h, respectively. After incubation, the cells are stained by 0.2% trypan blue and counted by Countess[2].
Animal Admin	Mice: 30 male mice (20–25 g, 7–8 weeks old) are used in this model. Briefly, mice are randomly divided into five groups; then mice are intraperitoneally injected with 50 μL DMSO (vehicle group) or sirtinol (2.5 or 5.0 mg/kg body weight). After 1 h, paw inflammation is induced . The thickness of the paw is measured before and after HNE or saline injection[3].
References	[1]. Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. [2]. Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. [3]. Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. [4]. Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.

Density	1.2±0.1 g/cm3
Boiling Point	659.2±50.0 °C at 760 mmHg
Melting Point	119-120℃
Molecular Formula	C₂₆H₂₂N₂O₂
Molecular Weight	394.465
Flash Point	352.5±30.1 °C
Exact Mass	394.168121
PSA	61.69000
LogP	6.20
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.623
Storage condition	−20°C
Water Solubility	Soluble in water, DMSO and methanol

WGK Germany	3
HS Code	2925290090

85592-80-9 structure

85592-80-9

708-06-5 structure

708-06-5

~96%

410536-97-9 structure

410536-97-9

Literature: US2009/137681 A1, ; Page/Page column 30; 32-33 ; US 20090137681 A1

Precursor 2
85592-80-9 708-06-5
DownStream 0

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%