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708-06-5

708-06-5 structure
708-06-5 structure
  • Name: 2-Hydroxy-naphthaldehyde
  • Chemical Name: 2-Hydroxy-1-naphthaldehyde
  • CAS Number: 708-06-5
  • Molecular Formula: C11H8O2
  • Molecular Weight: 172.18
  • Catalog: Chemical reagent Organic reagent Polycyclic compound
  • Create Date: 2018-04-17 08:00:00
  • Modify Date: 2025-08-23 07:53:42
  • CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].
Name 2-Hydroxy-1-naphthaldehyde
Synonyms 2-Hydroxy-1-naphthaldehyde
2-hydroxynaphthalene-1-carboxaldehyde
1-naphthalenecarboxaldehyde, 2-hydroxy
1-Naphthalenecarboxaldehyde, 2-hydroxy-
EINECS 211-902-0
2-Hydroxy-naphthaldehyde
MFCD00004005
.β.-Hydroxy-.α.-naphthaldehyde
Description CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].
Related Catalog
Target

KRAS(G12C)

In Vitro CFL-137 (72 h) 显示出抗增殖作用，对 H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 细胞的 IC50 值分别为 11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM[1]。
In Vivo CFL-137 (5 mg/kg，5 次治疗；15 mg/kg，5 次治疗；30 mg/kg，3 次治疗；i.p.) 减少皮下人肺癌 H1792 (KRasG12C 突变体) 和 LCLC-103H (KRasWT) 小鼠肿瘤模型的生长[1]。 Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 32.5%.
References

[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.  

Density 1.3±0.1 g/cm3
Boiling Point 305.8±0.0 °C at 760 mmHg
Melting Point 82-85ºC
Molecular Formula C11H8O2
Molecular Weight 172.18
Flash Point 134.3±13.0 °C
Exact Mass 172.052429
PSA 37.30000
LogP 2.84
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.719

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ0300000
CHEMICAL NAME :
1-Naphthaldehyde, 2-hydroxy-
CAS REGISTRY NUMBER :
708-06-5
BEILSTEIN REFERENCE NO. :
0742777
LAST UPDATED :
199709
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C11-H8-O2
MOLECULAR WEIGHT :
172.19
WISWESSER LINE NOTATION :
T66J BVH CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1170 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7250 mg/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased Blood - change in clotting factors Blood - changes in leukocyte (WBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H315-H319-H335-H400
Precautionary Statements P261-P273-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;N: Dangerous for the environment;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR UN 3077 9
WGK Germany 2
RTECS QJ0300000
HS Code 2912499000
HS Code 2912499000
Summary 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%
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