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106017-08-7

106017-08-7 structure
106017-08-7 structure
  • Name: Rufloxacin (hydrochloride)
  • Chemical Name: rufloxacin hydrochloride
  • CAS Number: 106017-08-7
  • Molecular Formula: C17H19ClFN3O3S
  • Molecular Weight: 399.86700
  • Catalog: API Synthetic anti-infective drugs Quinolone
  • Create Date: 2018-08-01 19:13:26
  • Modify Date: 2024-01-09 17:40:18
  • Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.
Name rufloxacin hydrochloride
Synonyms 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid,9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride(1:1)
MF-934
MFCD00912283
9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride
7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid,2,3-dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride
Rufloxacin (hydrochloride)
Description Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.
Related Catalog
Boiling Point 574.6ºC at 760mmHg
Melting Point 322-324ºC
Molecular Formula C17H19ClFN3O3S
Molecular Weight 399.86700
Flash Point 301.3ºC
Exact Mass 399.08200
PSA 91.08000
LogP 2.50120
Storage condition 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8174500
CHEMICAL NAME :
7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-10-(4-methyl-1- piperazinyl)-7-oxo-, monohydrochloride
CAS REGISTRY NUMBER :
106017-08-7
LAST UPDATED :
198709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H18-F-N3-O3-S.Cl-H
MOLECULAR WEIGHT :
399.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
501 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
224 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
HS Code 2942000000
108860-30-6 structure

108860-30-6

4637-24-5 structure

4637-24-5

60-23-1 structure

60-23-1

~71%

106017-08-7 structure

106017-08-7

Literature: Mediolanum Farmaceutici S.p.A. Patent: US5221741 A1, 1993 ;
138944-13-5 structure

138944-13-5

~88%

106017-08-7 structure

106017-08-7

Literature: Cecchetti; Fravolini; Schiaffella Synthetic Communications, 1991 , vol. 21, # 22 p. 2301 - 2308
108860-30-6 structure

108860-30-6

~%

106017-08-7 structure

106017-08-7

Literature: Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308
113933-55-4 structure

113933-55-4

~%

106017-08-7 structure

106017-08-7

Literature: Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308
138944-12-4 structure

138944-12-4

~%

106017-08-7 structure

106017-08-7

Literature: Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308
HS Code 2942000000
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