106017-08-7

• 常用中文名：盐酸鲁氟沙星(MF-934)
• 常用英文名：Rufloxacin (hydrochloride)
• CAS号：106017-08-7
• 分子式：C₁₇H₁₉ClFN₃O₃S
• 分子量：399.86700
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-08-01 19:13:26
• 更新时间：2024-01-09 17:40:18
• 【用途一】
  用于大肠杆菌、痢疾杆菌、流感杆菌等的感染

名称

• 中文名: 盐酸芦氟沙星
• 英文名: rufloxacin hydrochloride
• 中文别名: 2,3-二氢-9-氟-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噻嗪-6-羧酸盐酸盐
• 英文别名: 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid,9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride(1:1); MF-934; MFCD00912283; 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride; 7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid,2,3-dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride; Rufloxacin (hydrochloride)

物化性质

• 沸点: 574.6ºC at 760mmHg
• 熔点: 322-324ºC
• 分子式: C₁₇H₁₉ClFN₃O₃S
• 分子量: 399.86700
• 闪点: 301.3ºC
• 精确质量: 399.08200
• PSA: 91.08000
• LogP: 2.50120
• 储存条件: 2-8℃

生物活性

• 描述: Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种喹诺酮类抗菌剂,作用于人单核细胞,抑制B细胞分化, 且制剂拓扑异构酶抑。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU8174500 CHEMICAL NAME : 7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-10-(4-methyl-1- piperazinyl)-7-oxo-, monohydrochloride CAS REGISTRY NUMBER : 106017-08-7 LAST UPDATED : 198709 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H18-F-N3-O3-S.Cl-H MOLECULAR WEIGHT : 399.90 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 501 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 285 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 224 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

安全

• 海关编码: 2942000000

合成路线

108860-30-6 4637-24-5 60-23-1 ~71% 106017-08-7

文献：Mediolanum Farmaceutici S.p.A. Patent: US5221741 A1, 1993 ;

138944-13-5 ~88% 106017-08-7

文献：Cecchetti; Fravolini; Schiaffella Synthetic Communications, 1991 , vol. 21, # 22 p. 2301 - 2308

108860-30-6 ~% 106017-08-7

文献：Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308

113933-55-4 ~% 106017-08-7

文献：Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308

138944-12-4 ~% 106017-08-7

文献：Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308

上下游产品

上游产品  4
108860-30-6 4637-24-5 60-23-1 113933-55-4
下游产品  0

海关

海关编码	2942000000