Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pregnenolone sulfate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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1247-64-9

1247-64-9 structure

1247-64-9 structure

Name: Pregnenolone monosulfate
Chemical Name: pregnenolone sulfate
CAS Number: 1247-64-9
Molecular Formula: C₂₁H₃₂O₅S
Molecular Weight: 396.54100
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2017-10-12 22:22:44
Modify Date: 2024-01-21 11:53:22
Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

Name	pregnenolone sulfate

Description	Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease
Target	CB1 Receptor Human Endogenous Metabolite
In Vitro	The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].
In Vivo	Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
Animal Admin	Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1].
References	[1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.

Molecular Formula	C₂₁H₃₂O₅S
Molecular Weight	396.54100
Exact Mass	396.19700
PSA	89.05000
LogP	5.42320
Storage condition	-20°C