537-98-4

537-98-4 structure

Name: (E)-Ferulic acid
Chemical Name: Trans-Ferulic Acid
CAS Number: 537-98-4
Molecular Formula: C₁₀H₁₀O₄
Molecular Weight: 194.184
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-02-07 08:00:00
Modify Date: 2025-08-22 17:56:00
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

Name	Trans-Ferulic Acid
Synonyms	Coniferic acid (E)-4-Hydroxy-3-methoxycinnamic acid 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Metronidazole Benzoate trans-4-Hydroxy-3-methoxycinnamic acid,trans-Ferulic acid,Ferulic acid (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid Ferulic acid, trans- 3-(4-Hydroxy-3-methoxyphenyl)propenoic acid (2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acid 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, benzoate (ester) MFCD00004400 trans-4-Hydroxy-3-methoxycinnamic acid,Ferulic acid Ferulic acid, E- (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid caffeic acid 3-methyl ether Benzoylmetronildazole (E)-4-hydroxy-3-methoxy-Cinnamic acid (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid Trans-4-Hydroxy-3-methoxycinnamic acid (2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid (E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid 2-Methyl-5-nitro-1H-imidazole-1-ethyl benzoate Ferulic acid trans-Ferulic acid EINECS 208-679-7 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl benzoate

Description	(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bax
References	[1]. Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.

Density	1.3±0.1 g/cm3
Boiling Point	372.3±27.0 °C at 760 mmHg
Melting Point	168-172ºC
Molecular Formula	C₁₀H₁₀O₄
Molecular Weight	194.184
Flash Point	150.5±17.2 °C
Exact Mass	194.057907
PSA	66.76000
LogP	1.64
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.627
Stability	Stable. Incompatible with strong oxidizing agents.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UD3365500