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59-47-2

59-47-2 structure
59-47-2 structure
  • Name: Mephenesin
  • Chemical Name: 3-(2-methylphenoxy)propane-1,2-diol
  • CAS Number: 59-47-2
  • Molecular Formula: C10H14O3
  • Molecular Weight: 182.21600
  • Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
  • Create Date: 2018-03-10 08:00:00
  • Modify Date: 2025-08-22 22:41:54
  • Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.Target: NMDA receptor
Name 3-(2-methylphenoxy)propane-1,2-diol
Synonyms Myodetensine
Mefenesina
3-o-tolyloxypropane-1,2-diol
Anatensin
Decontractyl
Lissenphan
3-(o-tolyloxy)-1,2-propanediol
Cresoxydiol
mephenesin
Decontractil
3-(2-methylphenoxy)-propane-1,2-diol
Cresodiol
Lissephen
Density 1.152g/cm3
Boiling Point 153ºC(4 torr)
Melting Point 69ºC
Molecular Formula C10H14O3
Molecular Weight 182.21600
Flash Point 161.5ºC
Exact Mass 182.09400
PSA 49.69000
LogP 0.72700
Index of Refraction 1.545
Water Solubility Soluble in alcohol

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ1225000
CHEMICAL NAME :
1,2-Propanediol, 3-(o-tolyloxy)-
CAS REGISTRY NUMBER :
59-47-2
BEILSTEIN REFERENCE NO. :
2047373
LAST UPDATED :
199706
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C10-H14-O3
MOLECULAR WEIGHT :
182.24
WISWESSER LINE NOTATION :
Q1YQ1OR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 130,280,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
283 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
133 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,323,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,1272,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 248,3642,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 89,145,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy)
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,305,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
821 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
322 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84506 No. of Facilities: 166 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3053 (estimated)
Hazard Codes Xn
Risk Phrases 22-36
Safety Phrases 26
WGK Germany 2
RTECS TZ1225000
HS Code 2909309090
95-48-7 structure

95-48-7

96-24-2 structure

96-24-2

~96%

59-47-2 structure

59-47-2

Literature: Hadimani, Mallinath B.; Purohit, Meena K.; Vanampally, Chandrashaker; Van Der Ploeg, Randy; Arballo, Victor; Morrow, Dwane; Frizzi, Katie E.; Calcutt, Nigel A.; Fernyhough, Paul; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5071 - 5078
556-52-5 structure

556-52-5

95-48-7 structure

95-48-7

~64%

59-47-2 structure

59-47-2

Literature: Seth, Kapileswar; Roy, Sudipta Raha; Pipaliya, Bhavin V.; Chakraborti, Asit K. Chemical Communications, 2013 , vol. 49, # 52 p. 5886 - 5888
95-48-7 structure

95-48-7

56-81-5 structure

56-81-5

~%

59-47-2 structure

59-47-2

Literature: Yakugaku Zasshi, , vol. 74, p. 1273 Chem.Abstr., , p. 14668
96-24-2 structure

96-24-2

4549-72-8 structure

4549-72-8

~%

59-47-2 structure

59-47-2

Literature: Journal of the American Chemical Society, , vol. 72, p. 3716
63991-86-6 structure

63991-86-6

~%

59-47-2 structure

59-47-2

Literature: Van Elburg; Ormskerk; De Kloe; Boogaard Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 2 p. 147 - 167
25772-91-2 structure

25772-91-2

~%

59-47-2 structure

59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167
2210-79-9 structure

2210-79-9

~%

59-47-2 structure

59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167
95-48-7 structure

95-48-7

~%

59-47-2 structure

59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167
106-89-8 structure

106-89-8

~%

59-47-2 structure

59-47-2

Literature: Journal of Pharmacy and Pharmacology, , vol. 10, p. 47,59
HS Code 2909309090
Summary 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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