19088-73-4

19088-73-4 structure

Name: 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE
Chemical Name: 3-Cyanoumbelliferone
CAS Number: 19088-73-4
Molecular Formula: C₁₀H₅NO₃
Molecular Weight: 187.15200
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyran compound
Create Date: 2018-06-12 09:46:14
Modify Date: 2025-08-25 10:49:48
3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM[1].

Name	3-Cyanoumbelliferone
Synonyms	3-Cyano-7-hydroxycoumarin 7-hydroxy-2-oxochromene-3-carbonitrile 7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile

Description	3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Ki: 2.9 μM (MIF)[1]
References	[1]. Orita M, et al. Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J Med Chem. 2001 Feb 15;44(4):540-7.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932209090

105-56-6

95-01-2

~86%

19088-73-4

Literature: Synthetic Communications, , vol. 35, # 6 p. 785 - 790

109-77-3

95-01-2

~84%

19088-73-4

Literature: Journal of Heterocyclic Chemistry, , vol. 48, # 4 p. 799 - 802

1334740-01-0

19088-73-4

Literature: Organic Letters, , vol. 13, # 19 p. 5260 - 5263

330996-72-0

~92%

19088-73-4

Literature: Journal of Heterocyclic Chemistry, , vol. 46, # 6 p. 1392 - 1395

95-01-2

19088-73-4

Literature: Synthesis, , # 15 p. 2331 - 2334

117620-77-6

19088-73-4

Literature: Acta Pharmacologica Sinica, , vol. 34, # 11 p. 1437 - 1448

277309-36-1

19088-73-4

Literature: Archives of Biochemistry and Biophysics, , vol. 505, # 2 p. 186 - 193

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%