Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals

Z Hu, X Li, F Du, J Yang, W Niu, F Xu, F Wang…

Index: Acta Pharmacologica Sinica, , vol. 34, # 11 p. 1437 - 1448

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Citation Number: 2

Abstract

... Acta Pharmacologica Sinica (2013) 34: 1437–1448; doi: 10.1038/aps.2013.74; published online 23 Sep 2013. ... were collected predose and at 0 to 4, 4 to 10, 10 to 24, 24 to 34, and 34 to 48 h ... in rats (1.6 L·h −1 ·kg −1 ) and dogs (1.3 L·h −1 ·kg −1 ). The volume of distribution in ...