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65664-81-5

65664-81-5 structure
65664-81-5 structure
  • Name: Bis-ANS dipotassium
  • Chemical Name: Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
  • CAS Number: 65664-81-5
  • Molecular Formula: C32H22K2N2O6S2
  • Molecular Weight: 672.85300
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
  • Create Date: 2018-10-08 09:38:22
  • Modify Date: 2025-08-26 21:40:44
  • Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Name Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
Synonyms BIS-ANS
BIS-ANS DIPOTASSIUM SALT
4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT
potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate
4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot
8-Anilino-1-naphthalenesulfonic Acid Di
4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A
4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI
Description Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Related Catalog
In Vitro Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2].
References

[1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50.

[2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)
Molecular Formula C32H22K2N2O6S2
Molecular Weight 672.85300
Exact Mass 672.01900
PSA 155.22000
LogP 9.26300
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
Precursor  1

DownStream  0

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