151889-03-1

151889-03-1 structure

Name: UCM 608
Chemical Name: N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide
CAS Number: 151889-03-1
Molecular Formula: C₁₉H₂₀N₂O₂
Molecular Weight: 308.37
Catalog: Signaling Pathways GPCR/G Protein Melatonin Receptor
Create Date: 2017-07-26 10:50:07
Modify Date: 2024-01-02 14:51:45
UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4[1][2].

Name	N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide
Synonyms	Carcinine ditrifluoroacetate 2-PHENYLMELATONIN Tocris-0680 HMS3266J05

Description	UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	pKi: 10.7 (MT1)[1]. pKi: 10.4 (MT2)[1]
In Vitro	UCM 608 is a high affinity melatonin membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4 [1].
References	[1]. Radogna F, et al. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009;239(1):37-45. [2]. Mor, M., et al. Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands. Bioorganic & Medicinal Chemistry, 9(4), 1045–1057.