220792-57-4

220792-57-4 structure

Name: Aminopurvalanol A
Chemical Name: Aminopurvalanol A,(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
CAS Number: 220792-57-4
Molecular Formula: C₁₉H₂₆ClN₇O
Molecular Weight: 403.90900
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-07-14 20:50:27
Modify Date: 2025-08-26 20:34:14
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].

Name	Aminopurvalanol A,(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Synonyms	ng-97 aminopurvalanol a

Description	Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Cyclins/Cdk[1]
In Vitro	Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis[2]. Cell Cycle Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations. Apoptosis Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: 40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.
References	[1]. Bernabò N, et al. Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization. Front Physiol. 2017;8:1097. [2]. Rosania GR, et al. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc Natl Acad Sci U S A. 1999;96(9):4797-4802.

Density	1.4g/cm3
Boiling Point	639ºC at 760mmHg
Molecular Formula	C₁₉H₂₆ClN₇O
Molecular Weight	403.90900
Flash Point	340.2ºC
Exact Mass	403.18900
PSA	113.91000
LogP	4.54240
Vapour Pressure	3.34E-17mmHg at 25°C
Index of Refraction	1.678

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