Top Suppliers:I want be here
Related CAS#:
6138-79-0 550-70-9
51657-91-1 85148-82-9
15514-06-4 1795134-06-3
56-99-5 1562338-39-9
36625-96-4 335081-04-4
1403335-09-0 1420823-71-7
1403333-99-2 1403334-53-1
1403864-75-4 1403864-88-9
1403864-92-5 1402881-80-4
1403865-01-9 1403899-28-4

550-70-9

550-70-9 structure
550-70-9 structure
  • Name: Triprolidine hydrochloride
  • Chemical Name: triprolidine hydrochloride (anh.)
  • CAS Number: 550-70-9
  • Molecular Formula: C19H23ClN2
  • Molecular Weight: 314.85200
  • Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
  • Create Date: 2018-12-25 18:20:36
  • Modify Date: 2025-08-25 15:49:51
  • Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].
Name triprolidine hydrochloride (anh.)
Synonyms EINECS 208-985-0
MFCD00039044
Triprolidine Hydrochloride
Triprolidine HCl
Description Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].
Related Catalog
Target

H1 Receptor

In Vivo Triprolidine (292.81-1467.20 μg/kg; intrathecal injection) produces a dose-dependent effect of spinal motor and sensory block in rats[3]. Animal Model: Male Sprague-Dawley rat (300-350 g)[3] Dosage: 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg Administration: Intrathecal injection Result: Elicited a dose-dependent spinal block.
References

[1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30.

[2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7.

[3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.
Density 1.061g/cm3
Boiling Point 435.4ºC at 760mmHg
Melting Point 59-61ºC
Molecular Formula C19H23ClN2
Molecular Weight 314.85200
Flash Point 217.1ºC
Exact Mass 314.15500
PSA 16.13000
LogP 4.65740
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT7657000
CHEMICAL NAME :
Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, (E)-
CAS REGISTRY NUMBER :
550-70-9
LAST UPDATED :
199803
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C19-H22-N2.Cl-H
MOLECULAR WEIGHT :
314.89
WISWESSER LINE NOTATION :
T6NJ BYR D1&2- AT5NTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
495 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>5 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81570 No. of Facilities: 842 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81570 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2378 (estimated) No. of Female Employees: 1467 (estimated)
Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26-36
RIDADR UN 3249
WGK Germany 3
RTECS UT7658000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090
486-12-4 structure

486-12-4

~51%

550-70-9 structure

550-70-9

Literature: HIKAL LIMITED Patent: WO2009/84035 A1, 2009 ; Location in patent: Page/Page column 11-12 ;
13573-69-8 structure

13573-69-8

~%

550-70-9 structure

550-70-9

Literature: WO2007/141803 A2, ; Page/Page column 6-7 ;
Precursor  1

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:550-70-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 550-70-9 | Chemsrc address: https://www.chemsrc.com/en/baike/671765.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved