Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzoic acid,2-hydroxy-, 2-[(2-hydroxyphenyl)methylene]hydrazide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

3232-36-8

3232-36-8 structure

Name: SCS
Chemical Name: SCS,Salicylidenesalicylhydrazide
CAS Number: 3232-36-8
Molecular Formula: C₁₄H₁₂N₂O₃
Molecular Weight: 256.25700
Catalog: Chemical reagent Organic reagent 肼
Create Date: 2018-03-10 08:00:00
Modify Date: 2025-08-26 17:33:32
SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions[1].

Name	SCS,Salicylidenesalicylhydrazide
Synonyms	2-hydroxybenzoylhydrazone of 2-hydroxybenzoylhydrazine SCS salicylaldehyde o-hydroxybenzoylhydrazone MFCD00043494 N'-Salicylidenesalicylic hydrazide SALICYLIDENE SALICYLHYDRAZONE salicylaldehyde 2-hydroxybenzoylhydrazone 1-Salicylidene-2-salicyloylhydrazine EINECS 221-773-2 Salicylidene salicylhydrazide 1-Salicyloyl-2-salicylidenehydrazine SALICYLIC (2-HYDROXYBENZYLIDENE)HYDRAZIDE 2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE 2-hydroxybenzoylhydrazine 2-hydroxybenzoylhydrazone 2-Hydroxybenzylidene 2-hydroxybenzhydrazide

Description	SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	IC50: 32 nM (α2β1γ1θ; by VIPR measurement) IC50: 4.5 nM (α2β1γ1θ), 5.3 nM (α2β1γ1), 7.9 nM (α1β1γ2s) (Measured by using whole-cell patch clamp)[1]
In Vitro	SCS (0.1 nM-3 μM) 对表达 α2β1γ1θ、α2β1γ1 和 α1β1γ2s 受体的 Ltk- 细胞的 GABA EC20 电流有浓度依赖性抑制作用，而对 α2β3γ2s 和 α1β2γ2s 受体无影响[1]。 SCS 的抑制不依赖于电压或使用 (not voltage or use dependent)[1]。 SCS 抑制 GABAA 受体所必需的结构决定因素位于 β1 亚基的精氨酸 238 和甘氨酸 335 区域。β1 亚基的 T255 和 I308 对于 SCS 的抑制是必需的[1]。
In Vivo	SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) 使小鼠产生腹部收缩[2]。 SCS (10-75 mg/kg; i.p.; once) 在小鼠中显示出抗强直性和阶段性疼痛和辣椒素痛觉的抗痛觉活性[2]。 SCS (10-75 mg/kg; i.p.; once) 显示小鼠抗炎活性[2]。SCS (50 and 75 mg/kg; i.p.; once) 显示对神经性痛觉的抗痛觉活性[2]。 Animal Model: BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model[2] Dosage: 10, 25, 50, and 75 mg/kg Administration: IP, single dose Result: Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner. Animal Model: BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model[2] Dosage: 50 and 75 mg/kg Administration: IP, single dose Result: Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min.
References	[1]. Thompson SA, et al. Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. Br J Pharmacol. 2004 May;142(1):97-106. [2]. Rukh L, et al. Efficacy assessment of salicylidene salicylhydrazide in chemotherapy associated peripheral neuropathy. Eur J Pharmacol. 2020 Dec 5;888:173481.

Density	1.406g/cm3
Boiling Point	427.3ºC at 760mmHg
Melting Point	280-284°C
Molecular Formula	C₁₄H₁₂N₂O₃
Molecular Weight	256.25700
Flash Point	212.2ºC
Exact Mass	256.08500
PSA	81.92000
LogP	2.25260
Appearance	solid \| off-white
Index of Refraction	1.615
Storage condition	Store at RT
Water Solubility	DMSO: ~20 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2928000090

Precursor 2
90-02-8 936-02-7
DownStream 1
2491-96-5

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

3232-36-8	56980-10-0
35104-18-8	56980-09-7
39970-08-6	55305-44-7
55305-75-4	55305-52-7
71235-97-7	106372-19-4
1241677-24-6	1213494-33-7
1213303-17-3	1135040-86-6
1257420-56-6	1213218-19-9
1342567-01-4	1638744-24-7
1179460-03-7	1247900-44-2