95635-55-5

95635-55-5 structure

Name: Ranolazine
Chemical Name: Ranolazine
CAS Number: 95635-55-5
Molecular Formula: C₂₄H₃₃N₃O₄
Molecular Weight: 427.536
Catalog: Biochemical Inhibitor Transmembrane Transporters Calcium Channel Inhibitor
Create Date: 2018-05-09 08:00:00
Modify Date: 2024-01-02 06:30:50
Ranolazine is an antianginal medication.Target: Sodium ChannelRanolazine is believed to have its effects via altering the transcellular late sodium current. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level [1]. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia in rats [2]. The effects of ranolazine on the NaV 1.7 and NaV 1.8 sodium channels also make it potentially useful in the treatment of neuropathic pain. Ranolazine produced dose-dependant analgesia on mechanical allodynia induced by CFA injection, but had no effect on thermal hyperalgesia [3, 4].

Name	Ranolazine
Synonyms	(±)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide RAN D Renexa 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl] N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamid CVT 303 N-(2,6-diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]pipérazin-1-yl}acétamide (±)-4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide Ranolazine N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]-1-piperazineacetamide [14C]-Ranolazine Ran4 MFCD00864690 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6,dimethylphenyl)-aminocarbonylmethyl]-piperazine Ranexa N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]- N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide

Description	Ranolazine is an antianginal medication.Target: Sodium ChannelRanolazine is believed to have its effects via altering the transcellular late sodium current. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level [1]. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia in rats [2]. The effects of ranolazine on the NaV 1.7 and NaV 1.8 sodium channels also make it potentially useful in the treatment of neuropathic pain. Ranolazine produced dose-dependant analgesia on mechanical allodynia induced by CFA injection, but had no effect on thermal hyperalgesia [3, 4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Natural Products >> Others
References	[1]. Hale, S.L. and R.A. Kloner, Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther, 2006. 11(4): p. 249-55. [2]. Fraser, H., et al., Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol, 2006. 41(6): p. 1031-8. [3]. Gould, H.J., 3rd, et al., Ranolazine attenuates behavioral signs of neuropathic pain. Behav Pharmacol, 2009. 20(8): p. 755-8. [4]. Casey, G.P., et al., Ranolazine attenuation of CFA-induced mechanical hyperalgesia. Pain Med, 2010. 11(1): p. 119-26.

Density	1.2±0.1 g/cm3
Boiling Point	624.1±55.0 °C at 760 mmHg
Melting Point	119-1200C
Molecular Formula	C₂₄H₃₃N₃O₄
Molecular Weight	427.536
Flash Point	331.2±31.5 °C
Exact Mass	427.247101
PSA	74.27000
LogP	3.47
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.586
Storage condition	-20°C Freezer

Hazard Codes	Xi
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

Precursor 7
162712-35-8 1131-01-7 5294-61-1 2210-74-4
1427177-23-8 90-05-1 87-62-7
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

122312-55-4	95635-55-5
110445-25-5	1092804-87-9
1054624-77-9	1092804-88-0
95635-56-6	172430-45-4
172430-46-5	755711-09-2