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Hot CAS#:
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80-13-7

80-13-7 structure
80-13-7 structure
  • Name: halazone
  • Chemical Name: Halazone
  • CAS Number: 80-13-7
  • Molecular Formula: C7H5Cl2NO4S
  • Molecular Weight: 270.09000
  • Catalog: API Synthetic anti-infective drugs Disinfectant antiseptic
  • Create Date: 2018-05-03 08:00:00
  • Modify Date: 2024-01-02 12:05:36
  • Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].
Name Halazone
Synonyms Pantocide
Benzoesaeure-(sulfonsaeure-(4)-dichloramid)
Gynamide
EINECS 201-253-1
Zeptabs
p-Dichlorsulfamid-benzoesaeure
Halazon
Pantosid
Pentocid
4-dichlorosulfamoyl-benzoic acid
PANTOCID
4-Dichlorsulfamoyl-benzoesaeure
Halozone
MFCD00045858
4-[(dichloroamino)sulfonyl]-benzoic acid
Description Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].
Related Catalog
In Vitro Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation[1].
References

[1]. M Rack, et al. Effects of Some Chemical Reagents on Sodium Current Inactivation in Myelinated Nerve Fibers of the Frog. Biophys J. 1986 Oct;50(4):557-64.

[2]. Rema Iyer, et al. Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds. J Biomol Screen. 2006 Oct;11(7):782-91.
Density 1.717 g/cm3
Boiling Point 437ºC at 760 mmHg
Melting Point 213ºC
Molecular Formula C7H5Cl2NO4S
Molecular Weight 270.09000
Flash Point 218.1ºC
Exact Mass 268.93200
PSA 83.06000
LogP 2.76390
Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG8050000
CHEMICAL NAME :
Benzoic acid, p-(dichlorosulfamoyl)-
CAS REGISTRY NUMBER :
80-13-7
BEILSTEIN REFERENCE NO. :
2740018
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C7-H5-Cl2-N-O4-S
MOLECULAR WEIGHT :
270.09
WISWESSER LINE NOTATION :
QVR DSWNGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/40D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5800 mg/kg/5W-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Blood - pigmented or nucleated red blood cells

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
6666 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
Hazard Codes T+
RIDADR 1479
WGK Germany 3
RTECS DG8050000
Packaging Group III
Hazard Class 5.1
HS Code 2935009090
473-34-7 structure

473-34-7

~95%

80-13-7 structure

80-13-7
Literature: Saljoughian, M.; Sadeghi, M. T. Monatshefte fuer Chemie, 1986 , vol. 117, p. 553 - 556
138-41-0 structure

138-41-0

~%

80-13-7 structure

80-13-7
Literature: A Handbook of Antiseptics ,S.112
138-41-0 structure

138-41-0

~%

80-13-7 structure

80-13-7

106145-03-3 structure

106145-03-3
Literature: DE318899 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 769
138-41-0 structure

138-41-0
7782-50-5 structure

7782-50-5

~%

80-13-7 structure

80-13-7
Literature: A Handbook of Antiseptics ,S.112 DE318899 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 769
138-41-0 structure

138-41-0
14380-61-1 structure

14380-61-1

~%

80-13-7 structure

80-13-7
Literature: A Handbook of Antiseptics ,S.112 DE318899 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 769
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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