74857-22-0

74857-22-0 structure

Name: Bisdionin C
Chemical Name: 1,1'-trimethylenebis[theobromine]
CAS Number: 74857-22-0
Molecular Formula: C₁₇H₂₀N₈O₄
Molecular Weight: 400.39200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-03-13 02:51:59
Modify Date: 2025-08-25 17:17:55
Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively[1].

Name	1,1'-trimethylenebis[theobromine]
Synonyms	1,3-Bis-[theobrominyl-(1)]-propan bisdionin C 3,7,3',7'-tetramethyl-3,7,3',7'-tetrahydro-1,1'-propane-1,3-diyl-bis-purine-2,6-dione

Description	Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	GH18 Chitinases[1]
References	[1]. Schüttelkopf AW, et al. Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases. ACS Med Chem Lett. 2011;2(6):428-432. Published 2011 Mar 23.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport