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  • DC Chemicals Limited
  • China
  • Product Name: p-MPPI HCl
  • Price: $350.0/100mg $550.0/250mg $1100.0/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

220643-77-6

220643-77-6 structure
220643-77-6 structure
  • Name: p-MPPI hydrochloride
  • Chemical Name: 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide,hydrochloride
  • CAS Number: 220643-77-6
  • Molecular Formula: C25H28ClIN4O2
  • Molecular Weight: 578.87300
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-12-25 15:27:13
  • Modify Date: 2024-04-05 16:21:50
  • p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].

Name 4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide,hydrochloride
Synonyms 4-Iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)benzamide monohydrochloride
P-Mppi HCl
p-MPPI hydrochloride
p-MPPI monohydrochloride
Description p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
Related Catalog
Target

5-HT1A Receptor

In Vitro p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].
In Vivo p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2] Dosage: 0.5, 1.5, 4.5 mg/kg Administration: i.p. Result: Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
References

[1]. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.

[2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.

Boiling Point 657.5ºC at 760 mmHg
Molecular Formula C25H28ClIN4O2
Molecular Weight 578.87300
Flash Point 351.4ºC
Exact Mass 578.09500
PSA 48.91000
LogP 4.96870
Vapour Pressure 3.66E-17mmHg at 25°C
Hazard Codes Xi