314776-92-6
314776-92-6 structure
- Name: BP 897
- Chemical Name: N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide hydr ochloride (1:1)
- CAS Number: 314776-92-6
- Molecular Formula: C26H32ClN3O2
- Molecular Weight: 454.004
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2016-11-04 23:53:04
- Modify Date: 2024-01-09 19:46:15
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BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 µM, respectively).
| Name | N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide hydr ochloride (1:1) |
|---|---|
| Synonyms |
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrochloride (1:1)
N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide hydrochloride (1:1) N-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}-2-naphthamide hydrochloride (1:1) N-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide BP 897 |
| Description | BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 µM, respectively). |
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| Related Catalog | |
| Target |
Ki: 0.92 nM (D3 receptor), 61 nM (D2 receptor), 0.3 µM (D4 receptor), 3 µM (D1 receptor)[1]. |
| In Vitro | BP 897 is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with a Ki of 0.92 nM for D3 receptor, a 70 times lower affinity at the D2 receptor (Ki, 61 nM), and shows low affinities at D1 and D4 receptors (Ki = 3 and 0.3 µM, respectively). BP 897 also weakly binds to α1 and α2 adrenergic receptors (Ki = 60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki = 84 and 345 nM, respectively), and has negligible affinities (Ki > 1 µM) at muscarinic, histamine and opiate receptors. BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1.0 ± 0.3 nM, and increases mitogenesis, another D3-receptor-mediated response (EC50 = 3 ± 1 nM) in NG 108-15 cells expressing the human D3 receptor. However, BP 897 (1 µM) does not inhibit cyclic AMP accumulation or trigger mitogenesis in cells expressing the D2 receptor[1]. |
| In Vivo | BP 897 binds to D2-receptor in mouse striatum with an ED50 of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg. BP 897 (0, 0.05, 0.5, 1 mg/kg) inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects[1]. |
| References |
| Boiling Point | 654.5ºC at 760mmHg |
|---|---|
| Molecular Formula | C26H32ClN3O2 |
| Molecular Weight | 454.004 |
| Flash Point | 349.6ºC |
| Exact Mass | 453.218292 |
| PSA | 48.30000 |
| LogP | 5.56030 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |