25522-33-2

25522-33-2 structure

Name: Isoferulic acid
Chemical Name: trans-Isoferulic acid
CAS Number: 25522-33-2
Molecular Formula: C₁₀H₁₀O₄
Molecular Weight: 194.184
Catalog: Natural product Phenylpropanoid
Create Date: 2017-07-14 21:43:45
Modify Date: 2025-08-25 12:58:44
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].

Name	trans-Isoferulic acid
Synonyms	trans-3-(3-Hydroxy-4-methoxyphenyl)acrylic acid trans-3-Hydroxy-4-methoxycinnamic acid 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)- (E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid 3-(3-Hydroxy-4-methoxyphenyl)acrylic acid Isoferulic acid EINECS 247-071-6

Description	trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
References	[1]. Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of Clematis florida var. plena. Nat Prod Res. 2019 Oct;33(20):2925-2931. [2]. Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan;18(1):203-11.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport