126176-79-2

126176-79-2 structure

Name: Icariside E5
Chemical Name: 2-[(2R)-1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanyl]-4-[(1 E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl β-D-glucopyranoside
CAS Number: 126176-79-2
Molecular Formula: C₂₆H₃₄O₁₁
Molecular Weight: 522.542
Catalog: Natural product Lignans
Create Date: 2017-10-07 18:43:06
Modify Date: 2024-01-03 18:33:07
Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].

Name	2-[(2R)-1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanyl]-4-[(1 E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl β-D-glucopyranoside
Synonyms	β-D-Glucopyranoside, 2-[(1R)-2-hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]ethyl]-4-[(1E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl icariside E5 Icariside E5

Description	Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS[1]. Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal[2].
References	[1]. Xuelin Shi, et al. Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-Oxidation In Vitro. Molecules. 2019 Nov 7;24(22):4041. [2]. M Iorizzi, et al. New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity. J Agric Food Chem. 2001 Apr;49(4):2022-9.

Hazard Codes	Xi