924296-39-9

924296-39-9 structure

Name: HBX 41108
Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
CAS Number: 924296-39-9
Molecular Formula: C₁₃H₃ClN₄O
Molecular Weight: 266.64200
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-21 18:12:38
Modify Date: 2025-08-21 21:43:13
HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].

Name	7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Synonyms	7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile HBX41108

Description	HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
References	[1]. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95. [2]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

1187-42-4

207554-23-2

~40%

924296-39-9

Literature: Hybrigenics S.A. Patent: EP1749822 A1, 2007 ; Location in patent: Page/Page column 28 ; EP 1749822 A1

1223532-25-9

924296-39-9

Literature: ChemMedChem, , vol. 5, # 4 p. 552 - 558

Precursor 2
1187-42-4 207554-23-2
DownStream 0