Name | 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
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Synonyms |
7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
HBX41108 |
Description | HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2]. |
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Related Catalog | |
References |
Density | 1.66g/cm3 |
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Boiling Point | 604.9ºC at 760 mmHg |
Molecular Formula | C13H3ClN4O |
Molecular Weight | 266.64200 |
Flash Point | 319.6ºC |
Exact Mass | 266.00000 |
PSA | 90.43000 |
LogP | 2.08476 |
Index of Refraction | 1.725 |
~40% 924296-39-9 |
Literature: Hybrigenics S.A. Patent: EP1749822 A1, 2007 ; Location in patent: Page/Page column 28 ; EP 1749822 A1 |
~% 924296-39-9 |
Literature: ChemMedChem, , vol. 5, # 4 p. 552 - 558 |
Precursor 2 | |
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DownStream 0 |