HBX 41108

Modify Date: 2025-08-21 21:43:13

HBX 41108 Structure
HBX 41108 structure
 Common Name HBX 41108
CAS Number 924296-39-9 Molecular Weight 266.64200
Density 1.66g/cm3 Boiling Point 604.9ºC at 760 mmHg
Molecular Formula C13H3ClN4O Melting Point N/A
MSDS N/A Flash Point 319.6ºC

 Use of HBX 41108


HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].

 Names

Name 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Synonym More Synonyms

 HBX 41108 Biological Activity

Description HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].
Related Catalog
References

[1]. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.

[2]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

 Chemical & Physical Properties

Density 1.66g/cm3
Boiling Point 604.9ºC at 760 mmHg
Molecular Formula C13H3ClN4O
Molecular Weight 266.64200
Flash Point 319.6ºC
Exact Mass 266.00000
PSA 90.43000
LogP 2.08476
Index of Refraction 1.725

 Synthetic Route

2,3-Diamino maleonitrile structure

2,3-Diamino mal...

CAS#:1187-42-4

5-chloro-3H-indene-1,2-dione structure

5-chloro-3H-ind...

CAS#:207554-23-2

~40%

HBX 41108 Structure

HBX 41108

CAS#:924296-39-9

Literature: Hybrigenics S.A. Patent: EP1749822 A1, 2007 ; Location in patent: Page/Page column 28 ; EP 1749822 A1
N/A structure

N/A

CAS#:1223532-25-9

~%

HBX 41108 Structure

HBX 41108

CAS#:924296-39-9

Literature: ChemMedChem, , vol. 5, # 4 p. 552 - 558

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
HBX41108
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