Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: aplyronine A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

151923-84-1

151923-84-1 structure

Name: aplyronine A
Chemical Name: DL-Serine, N,N,O-trimethyl-, 24-[8-(acetyloxy)- 6-[2-(dimethylamino)-1-oxopropoxy]- 11-(formylmethylamino)-2-hydroxy- 1,3,7,9-tetramethyl-10-undecenyl]- 10-hydroxy-14,20-dimethoxy- 9,11,15,18-tetramethyl-2-oxooxacyclotetracosa- 3,5,15,21-tetraen-8-yl este
CAS Number: 151923-84-1
Molecular Formula: C₅₉H₁₀₁N₃O₁₄
Molecular Weight: 1076.44000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-01-30 09:39:17
Modify Date: 2025-08-25 14:33:22
Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].

Name	DL-Serine, N,N,O-trimethyl-, 24-[8-(acetyloxy)- 6-[2-(dimethylamino)-1-oxopropoxy]- 11-(formylmethylamino)-2-hydroxy- 1,3,7,9-tetramethyl-10-undecenyl]- 10-hydroxy-14,20-dimethoxy- 9,11,15,18-tetramethyl-2-oxooxacyclotetracosa- 3,5,15,21-tetraen-8-yl este
Synonyms	aplyronine A Serine,N,N,o-trimethyl-,(3E,5E,8R,9S,10R,11R,14S,15E,18R,20R,21E,24S)-24-((1S,2S,3S,6R,7S,8R,9R,10E)-8-(acetyloxy)-6-((2S)-2-(dimethylamino)-1-oxopropoxy)-11-(formylmethylamino)-2-hydroxy-1,3,7,9-tetramethyl-10-undecenyl)-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxooxacyclotetracosa-3,5,15,21-tetraen-8-yl ester

Description	Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	IC50: 0.01 nM (HeLa S3 cells)[1]. EC50: 1.3 μM (F-actin)[1]
In Vitro	Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with IC50 value of 0.01 nM[1]. Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1]. Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1]. Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1]. Western Blot Analysis[1] Cell Line: HeLa S3 cells Concentration: 0-1 μM Incubation Time: 0-2 h Result: Induced the dephosphorylation of FAK in HeLa S3 cells. Apoptosis Analysis[1] Cell Line: HeLa S3 cells Concentration: 100 nM Incubation Time: 24 h Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.
In Vivo	Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].
References	[1]. Masaki Kita, et al. Fluorescent aplyronine a: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells. Chembiochem. 2012 Aug 13;13(12):1754-8, 1702.

Density	1.09g/cm3
Boiling Point	988.8ºC at 760mmHg
Molecular Formula	C₅₉H₁₀₁N₃O₁₄
Molecular Weight	1076.44000
Flash Point	551.8ºC
Exact Mass	1075.73000
PSA	200.14000
LogP	8.37180
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.524

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