aplyronine A
Modify Date: 2025-08-25 14:33:22
aplyronine A structure
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Common Name | aplyronine A | ||
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| CAS Number | 151923-84-1 | Molecular Weight | 1076.44000 | |
| Density | 1.09g/cm3 | Boiling Point | 988.8ºC at 760mmHg | |
| Molecular Formula | C59H101N3O14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 551.8ºC | |
Use of aplyronine AAplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1]. |
| Name | DL-Serine, N,N,O-trimethyl-, 24-[8-(acetyloxy)- 6-[2-(dimethylamino)-1-oxopropoxy]- 11-(formylmethylamino)-2-hydroxy- 1,3,7,9-tetramethyl-10-undecenyl]- 10-hydroxy-14,20-dimethoxy- 9,11,15,18-tetramethyl-2-oxooxacyclotetracosa- 3,5,15,21-tetraen-8-yl este |
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| Synonym | More Synonyms |
| Description | Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1]. |
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| Related Catalog | |
| Target |
IC50: 0.01 nM (HeLa S3 cells)[1]. EC50: 1.3 μM (F-actin)[1] |
| In Vitro | Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with IC50 value of 0.01 nM[1]. Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1]. Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1]. Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1]. Western Blot Analysis[1] Cell Line: HeLa S3 cells Concentration: 0-1 μM Incubation Time: 0-2 h Result: Induced the dephosphorylation of FAK in HeLa S3 cells. Apoptosis Analysis[1] Cell Line: HeLa S3 cells Concentration: 100 nM Incubation Time: 24 h Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells. |
| In Vivo | Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1]. |
| References |
| Density | 1.09g/cm3 |
|---|---|
| Boiling Point | 988.8ºC at 760mmHg |
| Molecular Formula | C59H101N3O14 |
| Molecular Weight | 1076.44000 |
| Flash Point | 551.8ºC |
| Exact Mass | 1075.73000 |
| PSA | 200.14000 |
| LogP | 8.37180 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.524 |
| aplyronine A |
| Serine,N,N,o-trimethyl-,(3E,5E,8R,9S,10R,11R,14S,15E,18R,20R,21E,24S)-24-((1S,2S,3S,6R,7S,8R,9R,10E)-8-(acetyloxy)-6-((2S)-2-(dimethylamino)-1-oxopropoxy)-11-(formylmethylamino)-2-hydroxy-1,3,7,9-tetramethyl-10-undecenyl)-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxooxacyclotetracosa-3,5,15,21-tetraen-8-yl ester |