Name | Cyclopenthiazide |
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Synonyms |
UNII:VX4S2N85F5
UNII:T7817XC41U EINECS 212-012-5 cyclopenthiazide 6-Chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide UNII:866GEV195O 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide 3-Cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide Benesal (VAN) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide MFCD00865825 Tsiklometiazid |
Description | Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1]. |
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Related Catalog | |
In Vivo | Cyclopenthiazide (0.5 mg/kg; i.p.; daily, for 3 days; female Wistar rats) increases the excretion of p-aminohippurate (PAH) [1]. Animal Model: Female Wistar rats[1] Dosage: 0.5 mg/kg Administration: Intraperitoneal injection; daily, for 3 days Result: Stimulated p-aminohippurate (PAH) excretion. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 605.6±65.0 °C at 760 mmHg |
Melting Point | 238-242ºC |
Molecular Formula | C13H18ClN3O4S2 |
Molecular Weight | 379.883 |
Flash Point | 320.1±34.3 °C |
Exact Mass | 379.042725 |
PSA | 135.12000 |
LogP | 1.58 |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.601 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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~% 742-20-1 |
Literature: Journal of Organic Chemistry, , vol. 26, p. 2814 - 2818 |
~% 742-20-1 |
Literature: Journal of Organic Chemistry, , vol. 26, p. 2814 - 2818 |