cyclopenthiazide

Modify Date: 2025-08-25 17:49:55

cyclopenthiazide structure	Common Name	cyclopenthiazide
	CAS Number	742-20-1	Molecular Weight	379.883
	Density	1.5±0.1 g/cm3	Boiling Point	605.6±65.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₈ClN₃O₄S₂	Melting Point	238-242ºC
	MSDS	N/A	Flash Point	320.1±34.3 °C

Use of cyclopenthiazide

Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1].

Name	Cyclopenthiazide
Synonym	More Synonyms

Description	Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Cyclopenthiazide (0.5 mg/kg; i.p.; daily, for 3 days; female Wistar rats) increases the excretion of p-aminohippurate (PAH) [1]. Animal Model: Female Wistar rats[1] Dosage: 0.5 mg/kg Administration: Intraperitoneal injection; daily, for 3 days Result: Stimulated p-aminohippurate (PAH) excretion.
References	[1]. Bräunlich H. Postnatal development of kidney function in rats receiving thyroid hormones. Exp Clin Endocrinol. 1984 May;83(3):243-50.

Density	1.5±0.1 g/cm3
Boiling Point	605.6±65.0 °C at 760 mmHg
Melting Point	238-242ºC
Molecular Formula	C₁₃H₁₈ClN₃O₄S₂
Molecular Weight	379.883
Flash Point	320.1±34.3 °C
Exact Mass	379.042725
PSA	135.12000
LogP	1.58
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.601

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8750000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide

CAS REGISTRY NUMBER :: 742-20-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-Cl-N3-O4-S2

MOLECULAR WEIGHT :: 379.91

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ HG ISZW D1- AL5TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,325,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 232 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,325,1961

Hazard Codes	Xi

N/A

CAS#:92017-67-9

cyclopenthiazide

CAS#:742-20-1

Literature: Journal of Organic Chemistry, , vol. 26, p. 2814 - 2818

4-Amino-6-chlor...

CAS#:121-30-2

Cyclopentylacet...

CAS#:5623-81-4

cyclopenthiazide

CAS#:742-20-1

Literature: Journal of Organic Chemistry, , vol. 26, p. 2814 - 2818

Precursor 2
CAS#:121-30-2 4-Amino-6-chlor... CAS#:5623-81-4 Cyclopentylacet...
DownStream 0

UNII:VX4S2N85F5

UNII:T7817XC41U

EINECS 212-012-5

cyclopenthiazide

6-Chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide

UNII:866GEV195O

6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide

3-Cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide

6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Benesal (VAN)

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide

MFCD00865825

Tsiklometiazid

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China
Product Name: Cyclopenthiazide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
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Delivery: Inquiry
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China
Product Name: cyclopenthiazide
Price: ￥Inquiry/10g ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/25g
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
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