236098-40-1

236098-40-1 structure

Name: [Arg14,Lys15] Nociceptin
Chemical Name: [Arg14,Lys15]Nociceptin
CAS Number: 236098-40-1
Molecular Formula: C₈₂H₁₃₇N₃₁O₂₂
Molecular Weight: 1909.16000
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-01-06 20:34:03
Modify Date: 2024-04-05 19:06:23
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1].

Name	[Arg14,Lys15]Nociceptin
Synonyms	phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-arg-lys-asn-gln

Description	[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].
In Vivo	In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].
References	[1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498. [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

Safety Phrases	22-24/25
WGK Germany	3