92118-27-9
92118-27-9 structure
- Name: Fotemustine
- Chemical Name: Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
- CAS Number: 92118-27-9
- Molecular Formula: C9H19ClN3O5P
- Molecular Weight: 315.691
- Catalog: API Antineoplastic agents Alkylating agent
- Create Date: 2018-05-03 08:00:00
- Modify Date: 2025-08-25 16:48:37
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Fotemustine is a DNA-alkylating agent, with antitumor activity.
| Name | Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate |
|---|---|
| Synonyms |
Phosphonic acid, P-[1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester
MFCD00866278 Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea Fotemustine |
| Description | Fotemustine is a DNA-alkylating agent, with antitumor activity. |
|---|---|
| Related Catalog | |
| Target |
DNA Alkylator[1] |
| In Vitro | Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2]. |
| Cell Assay | Cell proliferation assays are performed using MTT. Briefly, cell suspensions containing 2 × 104 viable cells/mL are plated into 96-well dishes and allowed to attach for 48 h at 371C in a 5% CO2 atmosphere. The culture medium is then removed and the cells are incubated for two doubling times at 37°C in the culture medium containing fotemustine (10-3 to 10 mM). When tested, amifostine or WR-1065 (10-4 to 10 mM) is added before Fotemustine for 15 min. Control cultures are exposed to saline for 15 min and then allowed to grow for the same duration in complete culture medium[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 188 °C(lit.) |
| Melting Point | 85ºC |
| Molecular Formula | C9H19ClN3O5P |
| Molecular Weight | 315.691 |
| Flash Point | 104 °F |
| Exact Mass | 315.075073 |
| PSA | 107.11000 |
| LogP | 1.26 |
| Index of Refraction | 1.524 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P281 |
| Hazard Codes | Xi |
| Risk Phrases | R10:Flammable. R36/37:Irritating to eyes and respiratory system . R43:May cause sensitization by skin contact. |
| Safety Phrases | S16-S26-S36 |
| RIDADR | UN 3336 3/PG 2 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |