| In Vitro |
D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows a inhibitory effect on cell growth of rabbit skin fibroblasts[1]. D,L-erythro PDMP (50 μM; 3 days) has eytotoxic of rabbit skin fibroblasts on cell morphology[1]. D,L-erythro-PDMP do not affect the biosynthesis of glycosphingolipids[1]. D,L-erythro-PDMP (MDCK cells; 40 μM; 24 h) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2]. D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposes to cycloheximide[2]. Cell Proliferation Assay[1] Cell Line: rabbit skin fibroblast Concentration: 0, 12, 25, 50 μM Incubation Time: 0, 4, 7, 10 days Result: Showed a inhibitory effect on cell growth. Cell Cytotoxicity Assay[1] Cell Line: rabbit skin fibroblast Concentration: 50 μM Incubation Time: 3 days Result: Had eytotoxic on cell morphology.
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