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  • Product Name: 2'MeO6MF
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  • Purity: 98.0%
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Hot CAS#:
56-41-7 108-65-6
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141-78-6 1310-73-2
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89112-85-6

89112-85-6 structure
89112-85-6 structure
  • Name: 2'MeO6MF
  • Chemical Name: 2-(2-methoxyphenyl)-6-methylchromen-4-one
  • CAS Number: 89112-85-6
  • Molecular Formula: C17H14O3
  • Molecular Weight: 266.29100
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-06-19 19:39:44
  • Modify Date: 2024-04-02 12:13:50
  • 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and sedative effects. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
Name 2-(2-methoxyphenyl)-6-methylchromen-4-one
Synonyms 4H-1-Benzopyran-4-one,2-(2-methoxyphenyl)-6-methyl
2-(2-methoxyphenyl)-6-methyl-4H-chromen-4-one
2-(2-methoxy-phenyl)-6-methyl-chromen-4-one
Description 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and sedative effects. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
Related Catalog
Target

GABAA receptor[1]
In Vitro 2'MeO6MF (100-300 µM; 60 min) weakly displaces [3H]-flunitrazepam binding to rat brain synaptosomal membranes by 5-10%. 2'MeO6MF enhances [3H]-muscimol binding to rat brain synaptic membranes in a concentration-dependent manner yielding a mean Emax of 219.8% and apparent EC50=20.8 nM[1]. 2'MeO6MF (1-300 µM) enhances the response elicited by a low concentration of GABA in a concentration-dependent manner at recombinant α1β2γ2L GABAA receptors expressed in XenopusM oocytes. 2'MeO6MF enhances the response elicited by GABA at recombinant α1β1,3γ2L and α1β2 GABAA receptors without any direct activation[1]. 2'MeO6MF (1-10 µM; 60 min) increases tonic inhibitory currents in a concentration-dependent manner in granule cells[2]. 2'MeO6MF (100-1000 µM; 6.5 h) inhibits the LPS-induced increase of NFkB activity in RAWblueTM macrophage cells[2].
In Vivo 2'MeO6MF (1-100 mg/kg; i.p.) displays anxiolytic-like effects in the elevated plus maze and light/dark tests. 2'MeO6MF induces sedative effects at higher doses in the holeboard, actimeter and barbiturate-induced sleep time tests[1]. 2'MeO6MF (30 mg/kg; i.p.) increases tonic currents in layer 2/3 pyramidal neurons of mice after stroke[2]. 2'MeO6MF (0.1-30 mg/kg; i.p.) is neuroprotective and enhances functional recovery after focal cerebral ischaemia in mice[2]. Animal Model: Male Balb-c mice (8-10 weeks, 25-35 g)[1] Dosage: 1, 10, 30, 100 mg/kg Administration: I.p. Result: No overt acute toxicity was observed. Exerted anxiolytic effects at low doses and sedative effects at high doses without myorelaxant effects.
References

[1]. Karim N, et, al. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol. 2012 Feb;165(4):880-96.

[2]. Clarkson AN, et, al. The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. J Cereb Blood Flow Metab. 2019 Jul;39(7):1266-1282.
Molecular Formula C17H14O3
Molecular Weight 266.29100
Exact Mass 266.09400
PSA 39.44000
LogP 3.77700
88952-34-5 structure

88952-34-5

~96%

89112-85-6 structure

89112-85-6
Literature: Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
88951-97-7 structure

88951-97-7

~%

89112-85-6 structure

89112-85-6
Literature: Mazumdar; Karmakar; Tiwari; Banerjee; Banerji Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 845 - 847
1450-72-2 structure

1450-72-2

~%

89112-85-6 structure

89112-85-6
Literature: Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
106-44-5 structure

106-44-5

~%

89112-85-6 structure

89112-85-6
Literature: Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
140-39-6 structure

140-39-6

~%

89112-85-6 structure

89112-85-6
Literature: Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
579-75-9 structure

579-75-9

~%

89112-85-6 structure

89112-85-6
Literature: Mazumdar; Karmakar; Rangachari; Banerjee; Banerji Journal of the Indian Chemical Society, 1990 , vol. 67, # 11 p. 911 - 913
88952-34-5 structure

88952-34-5
127-09-3 structure

127-09-3
64-19-7 structure

64-19-7

~%

89112-85-6 structure

89112-85-6
Literature: Baker; Besly Journal of the Chemical Society, 1940 , p. 1103
21615-34-9 structure

21615-34-9

~%

89112-85-6 structure

89112-85-6
Literature: Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201

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title: CAS No. 89112-85-6 | Chemsrc address: https://www.chemsrc.com/en/baike/53635.html

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