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32884-36-9

32884-36-9 structure
32884-36-9 structure
  • Name: Cajanin
  • Chemical Name: 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxychromen-4-one
  • CAS Number: 32884-36-9
  • Molecular Formula: C16H12O6
  • Molecular Weight: 300.263
  • Catalog: Natural product Flavonoids
  • Create Date: 2016-04-04 14:46:19
  • Modify Date: 2025-08-25 10:36:16
  • Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis[1][2].
Name 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxychromen-4-one
Synonyms 5,2',4'-Trihydroxy-7-methoxyisoflavone
Cajanin
2',4',5-Trihydroxy-7-methoxyisoflavon
4H-1-Benzopyran-4-one, 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-
3-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one
2',4',5-trihydroxy-7-methoxyisoflavone
Description Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis[1][2].
Related Catalog
In Vitro Cajanin shows strong mitogenic as well as differentiation-promoting effects on osteoblasts[2]. Cajanin induces the phosphorylation of both Erk1/2 and Akt[2].
In Vivo Cajanin (10 mg/kg, p.o.; daily for 30 consecutive days) increases the BMD levels in all anatomical regions of the skeleton studied in Sprague Dawley rats[1].
References

[1]. Netcharoensirisuk P, et al. Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells. Molecules. 2021 Oct 5;26(19):6040.

[2]. Bhargavan B, et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 2009 Oct 1;108(2):388-99.

[3]. Wensaas AJ, et al. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes. 2009 Mar;58(3):527-35.
Density 1.5±0.1 g/cm3
Boiling Point 605.5±55.0 °C at 760 mmHg
Molecular Formula C16H12O6
Molecular Weight 300.263
Flash Point 231.7±25.0 °C
Exact Mass 300.063385
PSA 100.13000
LogP 3.57
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.697
Hazard Codes Xi
HS Code 2914509090
HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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