118068-30-7

118068-30-7 structure

Name: Amylin (20-29) (human)
Chemical Name: h-ser-asn-asn-phe-gly-ala-ile-leu-ser-ser-oh
CAS Number: 118068-30-7
Molecular Formula: C₄₃H₆₈N₁₂O₁₆
Molecular Weight: 1009.07
Catalog: Research Areas Neurological Disease
Create Date: 2019-01-15 10:32:11
Modify Date: 2024-01-10 19:41:50
Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2].

Name	h-ser-asn-asn-phe-gly-ala-ile-leu-ser-ser-oh
Synonyms	AMYLIN FRAGMENT 20-29 HUMAN SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER diabetes associated peptide fragment 20-29 human SNNFGAILSS

Description	Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Kapurniotu A, et al. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol. 2002 Jan 18;315(3):339-50. [2]. Elgersma RC, et al. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42.

Safety Phrases	22-24/25
WGK Germany	3