Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Diethyl pyrocarbonate
Price: ￥9000.0/1kg ￥88.0/5ml ￥288.0/25ml
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diethyl pyrocarbonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Diethyl pyrocarbonate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: diethyl pyrocarbonate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

1609-47-8

1609-47-8 structure

Name: Diethyl pyrocarbonate
Chemical Name: diethyl pyrocarbonate
CAS Number: 1609-47-8
Molecular Formula: C₆H₁₀O₅
Molecular Weight: 162.141
Catalog: Organic raw materials Inorganic acid ester
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-02 10:21:47
Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues[1].

Name	diethyl pyrocarbonate
Synonyms	Diethyl pyrocarbonate MFCD00009106 ethoxycarbonyl ethyl carbonate diethyl dicarbonate DEP,DEPC,Diethyl dicarbonate Diethyl pyrocarbonate (DEPC) Diethyl oxydiformate Ethoxyformic acid anhydride EINECS 216-542-8

Description	Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. E E Nattie. Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. J Appl Physiol (1985). 1986 Sep;61(3):843-50.

Density	1.2±0.1 g/cm3
Boiling Point	201.3±9.0 °C at 760 mmHg
Molecular Formula	C₆H₁₀O₅
Molecular Weight	162.141
Flash Point	69.4±0.0 °C
Exact Mass	162.052826
PSA	61.83000
LogP	1.48
Vapour Pressure	0.3±0.4 mmHg at 25°C
Index of Refraction	1.413
Storage condition	2-8°C
Stability	Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia.
Water Solubility	slow decomposition

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ9350000

CHEMICAL NAME :: Formic acid, oxydi-, diethyl ester

CAS REGISTRY NUMBER :: 1609-47-8

BEILSTEIN REFERENCE NO. :: 0637031

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H10-O5

MOLECULAR WEIGHT :: 162.16

WISWESSER LINE NOTATION :: 2OVOVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZLUFAR Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.86- 1943- Volume(issue)/page/year: 114,292,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1558 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 ppm/1H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	2810
WGK Germany	3
RTECS	LQ9350000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2920909090

541-41-3

~93%

1609-47-8

Literature: Plusquellec, Daniel; Roulleau, Fabienne; Lefeuvre, Martine; Brown, Eric Tetrahedron, 1988 , vol. 44, # 9 p. 2471 - 2476

541-41-3

124-30-1

1609-47-8

Literature: US5231211 A1, ;

5536-61-8

541-41-3

760-93-0

1609-47-8

Detail

Literature: US6346650 B1, ; Page column 6-7 ;

64-17-5

24424-99-5

27945-07-9

19935-69-4

Detail

Literature: Journal of Organic Chemistry, , vol. 65, # 20 p. 6368 - 6380

483-18-1

67-66-3

541-41-3

1609-47-8

Detail

Literature: Chemische Berichte, , vol. 71, p. 1797,1802

Precursor 7
541-41-3 124-30-1 5536-61-8 64-17-5
24424-99-5 483-18-1 67-66-3
DownStream 9
424-36-2 544-35-4 41430-70-0 32996-16-0
93-89-0 14619-42-2 180468-42-2 94-30-4
1847-84-3

HS Code	2920909090
Summary	2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

1609-47-8	87277-90-5
130948-55-9	77225-68-4
96824-27-0	105600-06-4
15326-95-1	51522-89-5
77644-13-4	71550-47-5