34240-05-6
34240-05-6 structure
- Name: Adenosine dialdehyde
- Chemical Name: Adenosine, periodate oxidized
- CAS Number: 34240-05-6
- Molecular Formula: C10H11N5O4
- Molecular Weight: 265.22500
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2018-04-05 08:00:00
- Modify Date: 2024-01-08 16:03:04
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Adenosine Dialdehyde is a purine nucleoside analogue and is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH) (IC50=40 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].
| Name | Adenosine, periodate oxidized |
|---|---|
| Synonyms |
ADENOSINE, PERIODATE OXIDIZED
α-adenosine 2',3'-dialdehyde ADENOSINE, PERIODATE OXIDISED Adenosine Dialdehyde |
| Description | Adenosine Dialdehyde is a purine nucleoside analogue and is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH) (IC50=40 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition[1]. |
| In Vivo | Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals[2]. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice[2]. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2]. Animal Model: Adult male A/J mice, weighing 20 to 25 g with MNB cells[2] Dosage: 1.5-2.5 mg/kg Administration: Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion) Result: Significantly suppressed murine neuroblastoma tumor growth. Prolongs the life span of tumor bearing mice. Did not suppress hematopoiesis when administered by steady state infusion[2]. |
| References |
| Molecular Formula | C10H11N5O4 |
|---|---|
| Molecular Weight | 265.22500 |
| Exact Mass | 265.08100 |
| PSA | 133.22000 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |