188591-67-5

188591-67-5 structure

Name: CP-101606 mesylate
Chemical Name: 1-[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol,methanesulfonic acid
CAS Number: 188591-67-5
Molecular Formula: C₂₁H₂₉NO₆S
Molecular Weight: 423.52
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2017-06-23 05:04:04
Modify Date: 2023-02-14 18:34:20
Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

Name	1-[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol,methanesulfonic acid
Synonyms	UNII-I23V4CCC9V Traxoprodil mesylate

Description	Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. [2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. [3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H319-H400
Precautionary Statements	P273-P301 + P310 + P330-P305 + P351 + P338-P391
Hazard Codes	T
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all