47295-77-2

47295-77-2 structure

Name: GPR
Chemical Name: (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CAS Number: 47295-77-2
Molecular Formula: C₁₃H₂₄N₆O₄
Molecular Weight: 328.36700
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-11-06 08:01:09
Modify Date: 2024-01-12 15:03:35
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

Name	(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Synonyms	Glycylprolylarginine Gly-pro-arg

Description	GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Neurological Disease
In Vitro	GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1]. GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1]. GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1]. GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1]. Apoptosis Analysis[1] Cell Line: p53-positive cells Concentration: 50 μM Incubation Time: 3 days Result: Inhibited Ah-induced increase in numbers of p53-positive neurons.