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339071-18-0

339071-18-0 structure
339071-18-0 structure
  • Name: TS-011
  • Chemical Name: N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
  • CAS Number: 339071-18-0
  • Molecular Formula: C11H14ClN3O2
  • Molecular Weight: 255.70100
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2017-12-13 16:12:45
  • Modify Date: 2025-08-25 14:00:58
  • TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
Name N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Synonyms TS-011
Methanimidamide,N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy
Description TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
Related Catalog
In Vivo TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2].
Animal Admin The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1].
References

[1]. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402.

[2]. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1350-4.

Boiling Point 477.8±55.0°C
Molecular Formula C11H14ClN3O2
Molecular Weight 255.70100
Exact Mass 255.07700
PSA 57.09000
LogP 2.27110
Storage condition 2-8°C
Hazard Codes Xi
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title: CAS No. 339071-18-0 | Chemsrc address: https://www.chemsrc.com/en/baike/454685.html

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