TS-011
Modify Date: 2025-08-25 14:00:58
TS-011 structure
|
Common Name | TS-011 | ||
|---|---|---|---|---|
| CAS Number | 339071-18-0 | Molecular Weight | 255.70100 | |
| Density | N/A | Boiling Point | 477.8±55.0°C | |
| Molecular Formula | C11H14ClN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TS-011TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. |
| Name | N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide |
|---|---|
| Synonym | More Synonyms |
| Description | TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. |
|---|---|
| Related Catalog | |
| In Vivo | TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2]. |
| Animal Admin | The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1]. |
| References |
| Boiling Point | 477.8±55.0°C |
|---|---|
| Molecular Formula | C11H14ClN3O2 |
| Molecular Weight | 255.70100 |
| Exact Mass | 255.07700 |
| PSA | 57.09000 |
| LogP | 2.27110 |
| InChIKey | ZTXADXBIGLLOFX-UHFFFAOYSA-N |
| SMILES | ONC=Nc1ccc(N2CCOCC2)c(Cl)c1 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|
| TS-011 |
| Methanimidamide,N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TS-011
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: TS-011
- Price: ￥888.0/50mg ￥2638.0/250mg
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMimidamide
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: TS-011
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/25mg ￥Inquiry/50mg
- Purity: 97.0%
- Delivery: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
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Price: ￥1585.2/250mg
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