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658-48-0

658-48-0 structure
658-48-0 structure
  • Name: a-methyl-D-tyrosine
  • Chemical Name: (S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
  • CAS Number: 658-48-0
  • Molecular Formula: C10H13NO3
  • Molecular Weight: 195.215
  • Catalog: Biochemical Amino acids and their derivatives Tyrosine derivatives
  • Create Date: 2018-06-16 11:44:35
  • Modify Date: 2025-08-26 20:42:50
  • α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA[1].
Name (S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Synonyms MFCD00004187
a-methyl-D-tyrosine
a-methyl-dl-p-tyrosine
EINECS 211-523-0
D-Tyrosine, α-methyl-
(-)-α-Methyl-D-tyrosine
D-tyrosine, a-methyl-
α-Methyl-D-tyrosine
Description α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA[1].
Related Catalog
References

[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9.
Density 1.3±0.1 g/cm3
Boiling Point 383.7±32.0 °C at 760 mmHg
Melting Point >300ºC(lit.)
Molecular Formula C10H13NO3
Molecular Weight 195.215
Flash Point 185.9±25.1 °C
Exact Mass 195.089539
PSA 83.55000
LogP 0.73
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.600
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YP2890000
CHEMICAL NAME :
Tyrosine, alpha-methyl-
CAS REGISTRY NUMBER :
658-48-0
BEILSTEIN REFERENCE NO. :
2938704
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H13-N-O3
MOLECULAR WEIGHT :
195.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 gm/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,435,1970
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YP2890000
HS Code 2922509090
HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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