a-methyl-D-tyrosine
Modify Date: 2024-01-02 03:44:34
a-methyl-D-tyrosine structure
|
Common Name | a-methyl-D-tyrosine | ||
|---|---|---|---|---|
| CAS Number | 658-48-0 | Molecular Weight | 195.215 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 383.7±32.0 °C at 760 mmHg | |
| Molecular Formula | C10H13NO3 | Melting Point | >300ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 185.9±25.1 °C | |
Use of a-methyl-D-tyrosineα-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA[1]. |
| Name | (S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 383.7±32.0 °C at 760 mmHg |
| Melting Point | >300ºC(lit.) |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.215 |
| Flash Point | 185.9±25.1 °C |
| Exact Mass | 195.089539 |
| PSA | 83.55000 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.600 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YP2890000 |
| HS Code | 2922509090 |
| Precursor 8 | |
|---|---|
| DownStream 3 | |
CAS#:123-08-0
CAS#:5619-08-9
CAS#:103-87-7
CAS#:84713-74-6
CAS#:84713-71-3
CAS#:7383-30-4
CAS#:13500-24-8
CAS#:16109-65-2
CAS#:103-86-6
CAS#:7434-77-7
CAS#:779-96-4| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|
Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.
Neuropharmacology 93 , 124-33, (2015) Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxi... |
|
|
Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.
Neuropharmacology 89 , 204-14, (2014) FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in re... |
|
|
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.
Endocrinology 156 , 2470-81, (2015) Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction be... |
| MFCD00004187 |
| a-methyl-D-tyrosine |
| a-methyl-dl-p-tyrosine |
| EINECS 211-523-0 |
| D-Tyrosine, α-methyl- |
| (-)-α-Methyl-D-tyrosine |
| D-tyrosine, a-methyl- |
| α-Methyl-D-tyrosine |