112226-61-6
112226-61-6 structure
- Name: HALOFENOZIDE
- Chemical Name: halofenozide
- CAS Number: 112226-61-6
- Molecular Formula: C18H19ClN2O2
- Molecular Weight: 330.81
- Catalog: analytical chemistry Standard Pesticides, veterinary drugs and fertilizers
- Create Date: 2018-07-30 20:31:18
- Modify Date: 2025-08-31 20:27:49
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Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1].
| Name | halofenozide |
|---|---|
| Synonyms |
RH 0345
N-tert-butyl-N’-(4-chlorobenzoyl)benzohydrazide N-tert-Butyl-N'-(4-chlorobenzoyl)benzohydrazide N'-benzoyl-N'-tert-butyl-4-chlorobenzohydrazide 4-chlorobenzoic acid 2-benzoyl-2-(1,1-dimethylethyl)hydrazide Mach 2 Halofenozide N’-benzoyl-N’-tert-butyl-4-chlorobenzohydrazide |
| Description | Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1]. Cell Viability Assay[2] Cell Line: Cultured ovaries were dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor) Concentration: 1 μM and 10 μM Incubation Time: 4 days Result: Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM. Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries. |
| In Vivo | After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1]. Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1]. Animal Model: Newly emerged (0-day-old) adult females of T. molitor [1] Dosage: 5 and 10 μg Administration: Topically applied Result: Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg) . |
| References |
| Density | 1.205g/cm3 |
|---|---|
| Melting Point | 198.0-199.0° |
| Molecular Formula | C18H19ClN2O2 |
| Molecular Weight | 330.81 |
| Exact Mass | 330.11400 |
| PSA | 49.41000 |
| LogP | 4.31660 |
| Index of Refraction | 1.584 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317-H411 |
| Precautionary Statements | P273-P280 |
| Hazard Codes | Xi,N |
| Risk Phrases | 43-51/53 |
| Safety Phrases | 24-37-61 |
| RIDADR | UN 3077 |
| RTECS | DG4976795 |
| Packaging Group | III |
| Hazard Class | 9 |
|
~%
112226-61-6 |
| Literature: EP982292 A2, ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |