112282-24-3

112282-24-3 structure

Name: BRL 52537 HYDROCHLORIDE
Chemical Name: BRL 52537 hydrochloride
CAS Number: 112282-24-3
Molecular Formula: C₁₈H₂₅Cl₃N₂O
Molecular Weight: 391.76
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-05-13 00:20:07
Modify Date: 2024-03-05 11:29:54
BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].

Name	BRL 52537 hydrochloride
Synonyms	(±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride Ethanone, 2-(3,4-dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]-, hydrochloride (1:1) 2-(3,4-Dichlorophenyl)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone hydrochloride (1:1) 2-(3,4-Dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]ethanone hydrochloride (1:1)

Description	BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Ki: 0.24 nM (κ-Opioid receptor) and 1560 nM (μ-Opioid receptor)[1]
References	[1]. Toru Goyagi, et al. Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke. 2003 Jun;34(6):1533-8.

Hazard Codes	Xi