Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-((4-(2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY)BENZO[B]THIOPHEN-7-YL)METHYL)THIAZOLIDINE-2,4-DIONE
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213411-83-7

213411-83-7 structure

Name: Edaglitazone
Chemical Name: 5-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione
CAS Number: 213411-83-7
Molecular Formula: C₂₄H₂₀N₂O₄S₂
Molecular Weight: 464.56
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-08-28 21:54:23
Modify Date: 2024-01-14 12:54:31
Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity[1][2][3].

Name	5-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione
Synonyms	UNII:8GKF7V499B EX-8519 5-({4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dione UNII-8GKF7V499B Edaglitazone 2,4-Thiazolidinedione, 5-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]- 5-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)methyl)thiazolidine-2,4-dione

Description	Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity[1][2][3].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Target	PPARγ:35.6 nM (EC50) PPARα:1053 nM (EC50)
In Vitro	Edaglitazone (3-16 μM; 5 min) inhibits the collagen (1.2 μg/mL)-induced platelet aggregation. Edaglitazone increases the intraplatelet levels of cAMP in a concentration dependent manner. Edaglitazone preventes the Collagen-induced intraplatelet levels of PPARγ decrease[3].
In Vivo	Edaglitazone (4.4 mg/kg; p.o. daily for 10 days) enhances insulin sensitivity in obese rats[2].
References	[1]. Dietz M, et, al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11. [2]. Fürnsinn C, et, al. Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br J Pharmacol. 1999 Nov;128(6):1141-8. [3]. Muñoz-Gutiérrez C, et, al. Study of the interactions between Edaglitazone and Ciglitazone with PPARγ and their antiplatelet profile. Life Sci. 2017 Oct 1;186:59-65.