Name | 2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol |
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Synonyms |
N-<3-<4-(2-Hydroxyoxyethyl)-piperazino>propyl>-2,2'-iminostilben
Opipramol 4-[3-(5H-Dibenz[b,f]azepin-5-yl)-propyl]-1-piperazineethanol 2-[4-(3-dibenzo[b,f]azepin-5-yl-propyl)-piperazin-1-yl]-ethanol Insidon Opipramolum [INN-Latin] opipramol hydrochloride [3H]-Opipramol EINECS 206-254-0 Opipramol [INN:BAN] Opipramol G Nisidana UNII-D23ZXO613C |
Description | Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2]. |
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Related Catalog | |
Target |
Ki: 50 nM (σ receptor); IC50: 5.5 μM ([3H] DA)[1]. |
In Vitro | Opipramol can potently interact with sigma recognition sites with a Ki value of 50 nM[1]. Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50 value of 5.5 μM[1]. |
In Vivo | Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo[2]. Animal Model: Sprague-Dawley rats (male, 150-l 80 g)[2] Dosage: 5-50 mg/kg Administration: Intraperitoneal injections Result: Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA. Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat. Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose. |
Density | 1.129 g/cm3 |
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Boiling Point | 555.1ºC at 760 mmHg |
Melting Point | 100-101ºC |
Molecular Formula | C23H29N3O |
Molecular Weight | 363.49600 |
Flash Point | 290.5ºC |
Exact Mass | 363.23100 |
PSA | 29.95000 |
LogP | 3.24930 |
Index of Refraction | 1.6500 (estimate) |
Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07, GHS09 |
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Signal Word | Warning |
Hazard Statements | H302-H410 |
Precautionary Statements | P273-P501 |
Hazard Codes | Xn,N |
Risk Phrases | 22-50/53 |
Safety Phrases | 60-61 |
RIDADR | UN 3077 9 / PGIII |
RTECS | TL8750000 |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |