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305-84-0

305-84-0 structure
305-84-0 structure
  • Name: L-carnosine
  • Chemical Name: carnosine
  • CAS Number: 305-84-0
  • Molecular Formula: C9H14N4O3
  • Molecular Weight: 226.232
  • Catalog: Biochemical Peptide
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2025-08-20 10:19:26
  • L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
Name carnosine
Synonyms (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid
N-b-Alanyl-L-histidine
EINECS 206-169-9
L-Histidine, N-β-alanyl-
β-Alanyl-L-histidine
N-(b-Alanyl)-L-histidine
N-β-Alanyl-L-histidin
beta-Alanyl-L-histidine
ignotine
n-2-m
L-IGNOTINE
carnosine
L-Histidine, N-(3-amino-1-hydroxypropylidene)-, (E)-
karnozzn
Carnosin
L-Carnosine
L-Histidine, β-alanyl-
MFCD00005207
N-β-Alanyl-L-histidine
(E)-N-(3-Amino-1-hydroxypropylidene)-L-histidine
Karnozin
H-β-Ala-His-OH
Description L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1]. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2].
References

[1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74.

[2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9.
Density 1.4±0.1 g/cm3
Boiling Point 656.2±55.0 °C at 760 mmHg
Melting Point 253 °C (dec.)(lit.)
Molecular Formula C9H14N4O3
Molecular Weight 226.232
Flash Point 350.7±31.5 °C
Exact Mass 226.106583
PSA 121.10000
LogP -2.17
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.591

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MS3080000
CHEMICAL NAME :
L-Histidine, N-beta-alanyl-
CAS REGISTRY NUMBER :
305-84-0
BEILSTEIN REFERENCE NO. :
0087671
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H14-N4-O3
MOLECULAR WEIGHT :
226.27
WISWESSER LINE NOTATION :
T5M CNJ D1YVQMV2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>14930 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9087 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
21 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1219,1974
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MS3080000
HS Code 2933290090
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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